Jenifer Lewis
Jackie Washington
Tim Curry
Edward Whatsett St. John
T.V. Blake
Antandra Washington (Jackie's Daughter)
Tangie Ambrose
Shaniqua Summers Wells (Jackie's Daughter)
Whoopi Goldberg
Nurse Ethyl Washington Rue Owens (Jackie's Sister)
Robert Bailey Jr.
Wilson Wells (Jackie's Grandson)
Tom Arnold
Marvin Pritz (Jackie's Former Manager)
Loretta Devine
Snookie Tate (Jackie's Childhood Friend)
Julie Hagerty
Pammy Dunbar (Infomercial Host)
David Hyde Pierce
Perry (The Deaf Rehearsal Pianist)