John Doe tell the story of a man who wakes up naked on an island off the coast of Seattle, knowing everything in the world there is to know—except for who he is and how and why he ended up there.
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John awakens to find himself stranded on an island off Seattle. His uncanny abilities are soon apparent to him when he is rescued by Asian fishermen and begins to speak the sailors' language fluently. When he sees a news report about a…

While continuing his quest to figure out who he is and from where he came, John Doe must use all his unique abilities to solve a gruesome murder case, initiated when a seemingly innocent individual dives into a swimming pool which he…

Victims turn up cut in half and the police call in John. DNA leads to a suspect locked up in an asylum who claims he can leave the place in dreams. John tracks the man's twin brother, actually a transsexual, and after another victim turns…

When skeletal remains are found at a construction site, the ownership is traced to a man who is a dead ringer for John.

Doe suspects a link to his own identity when a naked man with a similar brand and no recollection of who he is washes ashore from Horseshoe Island, similar to Doe's arrival in town.

Investigating a violent and seemingly impossible crime committed at the Seattle Museum of Art, John discovers that Karen is involved.

When a young boy Wesley and his mother approach John Doe claiming that sperm bank records indicate he is the boy's father, John is pulled into a mystery as he tries to track down the list of donors and finds two of them dead, their brains…

John discovers clues that lead to his real life, a trail that takes him to Idaho and raises more questions than answers.

John boards a flight for London but discovers a murder-mystery in mid-air while getting to know a pretty fellow passenger and neurologist.

The mysterious symbol on Doe's chest is part of the calling card left by a serial killer known as The Mourner who knows a lot about Doe, whom he challenges with cryptic clues as he puts more lives in danger.

Lenny renews his duel of wits with John, kidnapping Lt. Avery and sending a series of cryptic clues with a fatal deadline. A new captain makes things hard for John and he and Digger go off on their own to hunt down the killer. John meets…

When a young Seattle DJ is mysteriously murdered by a seemingly non-existent perpetrator, Doe helps unravel the enigma while pursuing a relationship with Rachel Pembroke (from 'Manifest Destiny').

The case of a mysteriously kidnapped teenage girl sends John Doe and Det. Frank Hayes on a frantic investigation to save her before it is too late.

Returning from Karen's art show, John thwarts a bomb threat but it's a ruse for the mysterious group that's been plaguing John to grab Karen. The group thinks John knows something about a staff with a phoenix on it and Karen may know it…

John copes with his first nightmare over Karen's death while helping the police in the deaths of several young girls. A psychic, Delphine, helps them locate two of the bodies in a nearby park. John is skeptical of her abilities but begins…

High school kids are surprised by a bright light in the forest and an astronaut who walks toward them that they shoot. The police and John investigate and determine the astronaut actually died of a lack of oxygen resulting in cyanosis but…

Ken Rothman, an ex-police officer that Avery got fired for beating a suspect, gets into the police HQ by faking his death and he and his men quickly take the station and most of the staff (except Frank) hostage. Rothman demands his…

A woman, Paulette, picks up a locked case and has it stolen, then comes to John for help. Moretti, a dead scientist, developed chips to augment the human brain and left them to her. John accepts, believing chip-augmented brain processes…

John is hit by lightning on his chest-brand and can see in color — going to see a fresh body, John realizes he's also lost access to his vast supply of knowledge and all the physical talents it provided. It's not a good time as a killer…

A man escapes from the Seneca Institute and is run over — Digger recognizes him as his blood brother Jay Dougan and John can see Dougan's picture in color. The two of them travel to Northam where the color leaves the dead man as John…

John begins to experience an onslaught of bizarre visions and images then blacks out — the visions lead him to a faceless murder victim and a cannery where the Phoenix Organization and the remote viewers were situated. John meets Sam of…
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